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Seven of 475 consecutive patients treated with thrombolysis for acute myocardial infarction had severe embolic complications that were believed to be caused by disintegration of pre-existing clot.Three patients had symptoms that persisted for many weeks,and five died.Any potential site of pre-existing blood clot within the vascular system,notably an enlarged left atrium,ventricular aneurysm,or aortic aneurysms,should be regarded as a contraindication to treatment with thrombolytic agents. |
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